Semi - Automated Operation

PTFC 2 Fraction Collector

Whenever automated sampling is required, the PTFC2 fraction collector together with a suitable pump offers an ideal choice. This instrument can be used with 6 or 12 position baths as well as with instruments of other manufacture. A basic sampling sequence can easily be programmed from the keypad on the PTFC2. The PTFC2 fraction collector can also be controlled via the keyboard of the PTWS dissolution bath. Connect the system components together and enter the sampling times for semi automated operation.

Peristaltic Pump

Our system compatible peristaltic pumps can be delivered in either an 8 or 16 channel version. It has to be emphasised that a peristaltic pump does not have a delivery accuracy of a syringe pump which is described below. Improvements in dosing accuracy can however, be achieved by slower pump revolution rates. 

This pump is supplied with either 8 or 12 syringes. Each position contains a 15 ml glass syringe and an integrated 3-way valve for sample obstruction and delivery. The instrument has firmware routines to ensure complete removal of all air in the sampling lines and syringes prior to sample dosing.

DFC-01 PT-DT7 Dissolution Tester connected to PTFC 2

A typical semi automated dissolution test system is composed of the following instruments: PT-DT7 Dissolution Bath, Sampling Tubes, Tygon or PTFE tubing installation, Peristaltic or Syringe Pump, and PTFC2 Fraction Collector. The pump can be supplied for a system without or with medium refilling; this defines the choice of either an 8 or 16 channel pump. The sampling program can be installed from the PTFC2 keypad and allows the collection of upto 20 sample sets with 7 samples in each set. The sampling tubes are permanently installed in the dissolution vessels. The sampling tubing sets maybe made up of either Tygon or Teflon.

DFC-02 PTWSIIIE / PTWS3CE Dissolution tester connected to PTFC2

A typical semi automated dissolution test system is composed of the following instruments PTWS lllE/PTWS3CE Dissolution Bath, S7ó Tubing Horness including sompletube holders, Tygon or PTFE tubing installation, Feristoltic or Syringe Pump, and a PTFC2 Fraction Collector.

DFC-03 PTWS 300 / PTWS 600 Dissolution Tester connected to PTFC2

Take samples from all 8 vessels using the EPE automated sampling manifold. In this case, the sampling tubes may either be left in the vessels during the dissolution period or placed in the vessels when required. After the sampling period, the EPE retracts and the sampling manifold is raised out of the solutions. Upgrade the system with the synchronous tablet drop magazine with combined vessel covers. Once again, pump selection as well as tubing material are based on individual requirements, as is the option for medium refilling.

DFC-12 PTWS 1200 Dissolution Tester connected to PTFC 12

Unlike the systems described above using the PTWS 12E and D6E, samples here may be taken either using fixed sampling tubes or the EPE adapted for 12 vessels. Again, use the modified double arm PTFC2 (PTFC 12) to collect up to 10 sample sets per 6 vessels. Medium refilling is also not possible with this particular configuration..

A typical semi automated dissolution test system is composed of the following instruments:
PTWD6E Dissolution Bath, 2 off s76 Tubing Hareness, Tygon or PTFE tubing installation, 2 Peristaltic or Syringe Pumps, and 2 PTFC2 Fraction Collectors.

DFC-1200 PTWS12E Dissolution Tester connected to PTFC 12

Using a modified PTFC2 (PTFC 12) with a double arm feature, samples may be taken from all 12 dissolution vessels (a maximum of 10 sets) and stored for subsequent analysis. Medium refilling in this configuration is not possible owing to the number of pumped sample lines. Use the 16 channel peristaltic pump or indeed the 12 station syringe pump for this application. The sampling tube types are the same as for the PTWS 3 series and remain in the sample vessels throughout the analysis, or EPE 12 automated sampling manifold is used.

DFC-MB6 PTW MB6 Dissolution Tester connected to PTFC2

Use the specially modified PTW-MB6 dissolution tester with moveable (motorised) water bath to collect samples from both types of media, with up to 20 sets of samples in total. In this case the modified EPE is actually fixed to the dissolution bath "head" and therefore moves with the head when it is raised to let the bath travel forward so that the dosage form may now be immersed and analysed in the second buffered medium (normally pH 6.8). Usea peristaltic or syringe pump for this application.

"Our workshop services all of the above equipment"